POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR Russian patent published in 2016 - IPC C07D213/26 C07D213/30 A61K31/44 A61P25/00 

Abstract RU 2604737 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula [I]: , where R1, R2, R3, R4 and R5 denote H; R6 denotes hydroxymethyl; A7 denotes C-R7, A8 denotes N and A9 denotes C-R9; R7, R9, R10 and R11 are selected independently from each other from H, C1-6-alkyl, C1-6-alkoxy, cyano and C1-6-alkylsulphonyl, where the said C1-6-alkyl or C1-6-alkoxy is optionally substituted with one or more substitutes selected from chlorine, fluorine and C1-6-alkoxy; and its pharmaceutically acceptable salts.

EFFECT: compounds are positive allosteric modulators (PAM) of nicotinic α7-receptor of acetylcholine.

13 cl, 1 tbl, 51 ex

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RU 2 604 737 C2

Authors

Eskildsen Jergen

Sams Anette Graven

Pjushl Ask

Dates

2016-12-10Published

2012-07-06Filed