C-FMC KINASE INHIBITORS Russian patent published in 2013 - IPC C07D401/12 C07D233/90 C07D405/12 C07D405/14 C07D409/12 A61K31/4178 A61K31/5355 A61K31/496 A61K31/382 A61K31/4418 A61P7/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to organic chemistry and specifically to compounds of formula I or pharmaceutically acceptable salts thereof, where W is where each R⁴ independently denotes H or CN; R² denotes a cycloalkyl which can be independently substituted with two of the following substitutes: C_(1-3)alkyl; Z denotes H; J denotes CH or N; X denotes or ; where R¹ denotes -OR^a, -CN, -NA¹A², -SO₂CH₃, -COOR^a, -CO₂CH₃, -CH₂-NA¹A², -CONA¹A², -CH₂OR^a, -NHCH₂CH₂OR^a, -OC_(1-4)alkylNA¹A², OCH₂CO₂R^a and tetrazolyl; R^z and R^y independently denotes H or -C_(1-4)alkyl, where both R^z may have syn or anti stereochemistry; alternatively both R^z in syn interaction may be taken together to form -(CH₂)_n-, where n equals 2; R₃ denotes C_(1-3)alkyl-CF₃ or -COCH₃; A¹ denotes H or -C_(1-4)alkyl; A² denotes H or -C_(1-4)alkyl; alternatively, A¹ and A may be taken together with a nitrogen atom with which they are bonded to form a heterocyclic ring selected from: , where R^a denotes H or C_(1-4)alkyl; R^bb denotes H, -C_(1-4)alkyl, and -CH₂CO₂H, where cycloalkyl relates to a partially unsaturated ring with 6 carbon atoms. The invention also relates to specific compounds of formula I, a pharmaceutical composition based on the compound of formula I and methods of treating inflammation and autoimmune diseases.

EFFECT: novel compounds of formula I which are useful as c-fms inhibitors are obtained.

10 cl, 2 tbl, 44 ex