CATALYST AND METHOD OF PRODUCING PYRAZINAMIDE Russian patent published in 2010 - IPC B01J23/22 B01J21/06 B01J23/24 C07D241/12 

FIELD: chemistry.

SUBSTANCE: invention relates to catalysts for pyrazinamide synthesis during reaction of oxidative ammonolysis methylpyrazine. Alkyl-substituted pyrazines and their derivatives have high biological activity, which enables their wide use as medicinal agents for different purposes. Described is a catalyst for synthesis of oxidative ammonolysis methylpyrazine containing vanadium pentoxide and titanium dioxide and modifying additives from a group of elements of oxidative nature such as tungsten W or molybden Mo, with the following content of components, wt %: V₂O₅ 10-29, TiO₂ 70-79, WoO₃ or MoO₃ 1-10. Also described is a method of producing pyrazinamide through oxidative ammonolysis methylpyrazine in the presence the catalyst described above.

EFFECT: proposed catalysts enable production of pyrazinamide in a single step and increase total output of pyrazinamide and pyrazinonitrile.

2 cl, 8 ex, 1 tbl