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(19)

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2 382 780

(13)

(51)

IPC

C07D405/12(2006-01-01)

C07D417/14(2006-01-01)

C07D417/12(2006-01-01)

C07D401/14(2006-01-01)

C07D207/16(2006-01-01)

C07D209/52(2006-01-01)

C07D211/36(2006-01-01)

A61K31/4025(2006-01-01)

A61K31/443(2006-01-01)

A61K31/403(2006-01-01)

A61K31/401(2006-01-01)

A61P37/00(2006-01-01)

(21) (22)

Application

2006134258/04, 2005-02-28

(24)

Start date

2005-02-28

(22)

Actual filing date

2005-02-28

(45)

Published

2010-02-27

(72)

Inventor

Sharr'E Zhan-Dam'EnDarrant StivenMortimor MajklO`Donnell MajklRezerford EhlisterRamaja SharnStadli Dzhon R.Trjudo MartehnLuker Adam

(73)

Holder

Verteks Farmas'Jutikalz Inkorporejted

CASPASE INHIBITORS AND USE THEREOF Russian patent published in 2010 - IPC C07D405/12 C07D417/14 C07D417/12 C07D401/14 C07D207/16 C07D209/52 C07D211/36 A61K31/4025 A61K31/443 A61K31/403 A61K31/401 A61P37/00

Abstract RU 2382780 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula I: where A,Y,R and R² assume values given in the description. The invention also relates to methods of producing compounds of formula I and their intermediate compounds, pharmaceutical compositions and methods of using the compounds and their pharmaceutical compositions for inhibiting caspase.

EFFECT: novel compounds have useful biological properties.

44 cl, 5 tbl, 66 ex

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RU 2 382 780 C2

Authors

Sharr'E Zhan-Dam'En

Darrant Stiven

Mortimor Majkl

O`Donnell Majkl

Rezerford Ehlister

Ramaja Sharn

Stadli Dzhon R.

Trjudo Martehn

Luker Adam

Dates

2010-02-27—Published

2005-02-28—Filed