FIELD: chemistry.
SUBSTANCE: present invention relates to pyrazine compounds 
, used as inhibitors of ATR protein kinase, pharmaceutical compositions containing compounds according to invention, and use of compounds according to present invention to increase cell sensitivity to DNA damaging agents and as a radio-sensitiser and a chemo-sensitiser.
EFFECT: high sensitivity of cells to DNA damaging agents, radio-sensitiser and chemo-sensitiser.
115 cl, 98 dwg, 18 tbl, 77 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NEW PHOSPHORAMIDATE NUCLEOSIDE DERIVATIVES AND APPLICATION THEREOF | 2014 |
|
RU2621709C2 |
| CONDENSED TRICYCLIC DERIVATIVES FOR TREATING PSYCHOTIC DISORDERS | 2005 |
|
RU2409582C2 |
| AZAADAMANTANE DERIVATIVES AND METHODS FOR APPLYING | 2007 |
|
RU2450002C2 |
| PROCESSES FOR MAKING COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | 2012 |
|
RU2677292C2 |
| PYRAZOLE DERIVATIVES APPLIED AS PROTEIN KINASE INHIBITORS | 2001 |
|
RU2340611C2 |
| QUINOLINE AND QUINAZOLINE DERIVATIVES WITH AFFINITY TO 5HT-RECEPTORS | 2004 |
|
RU2402533C2 |
| KINASE INHIBITORS APPLICABLE FOR TREATING MYELOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | 2007 |
|
RU2482112C2 |
| IMIDAZOLE DERIVATIVES AS TAFIa INHIBITORS | 2005 |
|
RU2375356C2 |
| BICYCLIC AMINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | 2007 |
|
RU2465275C2 |
| PYRROLOPYRIDINES EFFECTIVE AS PROTEINKINASE INHIBITORS | 2006 |
|
RU2435769C2 |
