FIELD: chemistry.
SUBSTANCE: present invention relates to pyrazine compounds , used as inhibitors of ATR protein kinase, pharmaceutical compositions containing compounds according to invention, and use of compounds according to present invention to increase cell sensitivity to DNA damaging agents and as a radio-sensitiser and a chemo-sensitiser.
EFFECT: high sensitivity of cells to DNA damaging agents, radio-sensitiser and chemo-sensitiser.
115 cl, 98 dwg, 18 tbl, 77 ex
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Authors
Dates
2016-12-10—Published
2009-12-18—Filed