PRODRUG OF FLUORINE-CONTAINING AMINO ACID Russian patent published in 2017 - IPC C07C229/50 C07C237/04 C07C237/20 C07C271/24 C07C323/60 C07D207/08 C07D307/88 C07D317/40 C07D317/50 A61K31/265 A61K31/357 A61P25/00 A61P25/08 A61P25/14 A61P25/16 A61P25/20 A61P25/24 A61P25/28 A61P25/30 

Abstract RU 2639868 C1

FIELD: pharmacology.

SUBSTANCE: in formula (I) R1 and R2 each represents a hydrogen atom, formula -(CR4R4')-O-CO-R5, or -(CR6R6')-O-CO-OR7, or formula (IIa) or (IIb), R3 represents a hydrogen atom, formula -(AA)n-H, -CO-O-(CR9R9')-O-CO-R10, or -CO-O-(CR9R9')-O-CO-OR11, or formula (III), R4 and R4' each represents a hydrogen atom or a C1-6alkyl group, R5 is a C1-10alkyl, adamantyl or phenyl group, R6 and R6'each represents a hydrogen atom or C1-6alkyl group, R7 is a C1-10alkyl, C3-8cycloalkyl or adamantyl group, R8 is a C1-6alkyl group, R9 and R9' each represents a hydrogen atom or C1-6alkyl group, R10 is a C1-10alkyl group, R11 is a C3-8cycloalkyl group, R12 is a C1-6alkyl group, AA is an aminoacyl group and n is an integer from 1 to 3.

EFFECT: application of compounds for prevention or treatment of the diseases listed above.

17 cl, 7 tbl, 42 ex

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RU 2 639 868 C1

Authors

Khasikhayata Takasi

Otake Norikadzu

Miyakosi Naoki

Sakagami Kazunari

Dates

2017-12-25Published

2013-05-31Filed