PYRIDIN-3-YL DERIVATIVES AS IMMUNOMODULATORY AGENTS Russian patent published in 2012 - IPC C07D413/04 C07D417/04 A61K31/4439 A61P37/00 A61P19/00 A61P35/00 A61P9/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pyridine-3-yl derivatives of formula (I)

wherein A represents *-CONH-CH₂-, *-CO-CH=CH-, *-CO-CH₂CH₂-, or wherein asterisks specify a link which binds with a pyridine group of formula (I); R¹ represents hydrogen, C_1-4alkyl or chlorine; R² represents C_1-5alkyl or C_1-4alkoxy group; R⁴ represents hydrogen or C_1-4alkyl; R⁴ represents hydrogen, C_1-4alkyl_; C_1-4alkoxy group or halogen; R⁵ represents -CH₂-(CH₂)_n- CONR⁵¹R⁵², -CO-NHR⁵¹, 1-(3-carboxyazetidinyl)-2-acetyl, hydroxy group, hydroxyC_2-5alkoxy group, di-(hydroxy C_1-4alkyl) C_1-4alkoxy group, 2,3-dihydroxypropoxy group, 2-[(azetidine-3-carboxylic acid)-1-yl]ethoxy group, -OCH₂-CH(OH)-CH₂-NR⁵¹R⁵² or -OCH₂-CH(OH)-CH₂-NHCOR⁵⁴; R⁵¹ represents hydrogen, C_1-3alkyl, 2-hydroxyetyl, 2-hydroxy-1-hydroxymethyletyl or 2,3-dihydropropyl; R⁵² represents hydrogen; R⁵⁴ represents hydroxymethyl; n represents 0 or 1; and R⁶ represents hydrogen, C_1-4alkyl or halogen; and a salt of said compound. Also the invention describes a pharmaceutical composition for prevention or treatment of diseases or conditions associated with activated immune system, on the basis of the compound of formula I and application of said compounds for preparing said pharmaceutical composition.

EFFECT: there are produced and described new compounds which are especially active as immunomodulatory agents.

18 cl, 92 ex, 2 tbl