IMPROVED PROCESS OF OBTAINING LINEZOLID Russian patent published in 2022 - IPC C07D413/06 C07D263/20 

FIELD: chemical or physical processes.

SUBSTANCE: invention relates to an improved process for producing a compound of formula (I)

,

which involves the following steps: a) reaction of a compound of formula (III) with (S)-glycidyl phthalimide of formula (IX) in a solvent in the presence of a metal hydride at temperature of 50–60 °C, where temperature of 50–60 °C is maintained for 2–3 hours to obtain a compound of formula (VI),

, , ,

in the above formula R is methyl , b) treating the compound of formula (VI) with an aqueous solution of methylamine or hydrazine hydrate, c) acylating the reaction product of step b) with an acylating substance and d) recovering a product of formula (I), wherein the method according to claim 1 is carried out in a molar ratio at step a) of the compound with formula (III) to (S)-glycidyl phthalimide of formula (IX) and a metal hydride corresponding to 0.098:0.123:0.05.

EFFECT: improved method of producing linezolid, which reduces process time and leads to obtaining a product with high output of high purity.

3 cl, 11 ex