METHOD FOR OBTAINING 5-CHLORO-N-(5S)-2-OXO-3-[4-(3-OXO-MORPHOLINYL)-PHENYL]-1,3-OXAZOLIDIN-5-YL}-METHYL)-2-THIOPHENECARBOXAMIDE IN MODIFICATION II (VERSIONS) Russian patent published in 2016 - IPC C07D413/14 A61K31/5377 A61P7/02 

FIELD: chemistry.

SUBSTANCE: invention relates to method for obtaining 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide, represented by formula

,

in modification II (thereof versions). Method for obtaining formula (I) in modification II, characterised by the following spectral data in nearest IR region [cm^-1]: 4086, 4228, 4418, 4457, 4634, 4905, 5846, 5911, 6026, 6081, 6582, consists in the fact that compound of formula (I) in modification I, characterised by the following spectral data in nearest IR region [cm^-1]: 4082, 4142, 4170, 4228, 4299, 4376, 4429, 4479, 4633, 4791, 4877, 4907, 5081, 5760, 5885, 6002, 6441, 6564, 8473, 8833, is dissolved in inert solvent, selected from the group, including acetone, tetrahydrofuran, 1-pentanol and their mixtures, and compound is precipitated by addition of n-heptane additive at temperatures within from 0 to 80°C. Method for obtaining compound of formula (I) in modification II, is also realised by dissolution of compound (I) in modification I in 1,4-dioxane, with exposure of solution at temperature within from 30°C to temperature of solvent reflux till complete solvent evaporation. Method for obtaining compound of formula (I) in modification II is realised by suspending compound (I) in modification I in ethanol with mixing or shaking suspension at temperature within from 20 to 25°C until transformation into modification II occurs.

EFFECT: obtaining 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide, represented by formula

,

in modification II, possessing high solubility.

4 cl, 12 dwg, 7 tbl, 2 ex