FIELD: chemistry.
SUBSTANCE: method involves crystallisation of iodixanol from a crude product containing approximately 75-90 wt % iodixanol, 3-10 wt % iohexol, 3-7 wt % 5-acetamido- N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodisophthalamide and trace amounts of other impurities in a solvent containing 1-methoxy-2-propanol. As a rule, the crystallisation process comprises a single step and lasts a total of 1-4 days, mainly approximately 2 days.
EFFECT: high output of desired product.
12 cl, 1 dwg, 4 ex
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