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(19)

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2 386 639

(13)

(51)

IPC

C07K16/28(2006-01-01)

C12N15/13(2006-01-01)

C12N15/63(2006-01-01)

A61K39/395(2006-01-01)

A61P37/00(2006-01-01)

A61P43/00(2006-01-01)

(21) (22)

Application

2006112598/13, 2004-09-17

(24)

Start date

2004-09-17

(22)

Actual filing date

2004-09-17

(45)

Published

2010-04-20

(72)

Inventor

Kol'Binger FrankKarballido-Ehrerra Khose M.Asodi AndrashSaldana Khose U.Kholl Brjus M.Gregori Sil'VijaRonkarolo Marija GratsijaLu VeronikAversa GregorioJeshke Margit

(73)

Holder

Novartis Ag

LINKING MOLECULES HAVING THERAPEUTIC ACTIVITY Russian patent published in 2010 - IPC C07K16/28 C12N15/13 C12N15/63 A61K39/395 A61P37/00 A61P43/00

Abstract RU 2386639 C2

FIELD: chemistry.

SUBSTANCE: invention relates to immunology and biotechnology. Described are versions of the humanised antibody CD45RO/RB which carry a light and a heavy strand. Versions of the following are disclosed: isolated polynucleotide, coding antibody, expression vector containing a polynucleotide and host cells containing the expression vector. Described also is use of the antibody to treat and/or prevent various diseases, including as a component of a pharmaceutical composition.

EFFECT: invention provides antibodies identified as CD45RO and CD45RB, which can find use in medicine.

9 cl, 14 dwg, 2 tbl, 13 ex

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RU 2 386 639 C2

Authors

Kol'Binger Frank

Karballido-Ehrerra Khose M.

Asodi Andrash

Saldana Khose U.

Kholl Brjus M.

Gregori Sil'Vija

Ronkarolo Marija Gratsija

Lu Veronik

Aversa Gregorio

Jeshke Margit

Dates

2010-04-20—Published

2004-09-17—Filed