Show metadata Hide metadata

(19)

(11)

2 609 627

(13)

(51)

IPC

C07K16/24(2006-01-01)

C12N15/63(2006-01-01)

A61K39/395(2006-01-01)

(21) (22)

Application

2014138740, 2014-09-26

(24)

Start date

2014-09-26

(22)

Actual filing date

2014-09-26

(45)

Published

2017-02-02

(72)

Inventor

Ulitin Andrej BorisovichSolovev Valerij VladimirovichNemankin Timofej AleksandrovichGoncharova Olga VladimirovnaEkimova Viktoriya MikhajlovnaEvdokimov Stanislav RudolfovichChernykh Yuliya SergeevnaKorzhavin Dmitrij ValerevichSofronova Ekaterina VladimirovnaChernovskaya Tatyana VeniaminovnaUstyugov Yakov YurevichIvanov Roman AlekseevichMorozov Dmitrij Valentinovich

(73)

Holder

Zakrytoe Aktsionernoe Obshchestvo

HIGH AFFINITY AND AGGREGATIONALLY STABLE ANTIBODIES BASED ON VL VARIABLE DOMAINS AND VHH DERIVATIVE Russian patent published in 2017 - IPC C07K16/24 C12N15/63 A61K39/395

Abstract RU 2609627 C2

FIELD: medicine, pharmacy.

SUBSTANCE: invention refers to biochemistry. A humanized IgG type monoclonal antibody that binds to human 17A interleukin is proposed. The antibody contains variable domains as a combination of VHH derivative with a light chain VL variable domain. The said VHH derivative contains amino acid substitutions at positions 44 and 45 (according to Kabat numbering). The invention also refers to DNA encoding the antibody, expression vector, cell line and a method for production of the said antibody. Furthermore, a pharmaceutical composition for treatment of IL-17A-mediated disease or disorder, comprising the antibody is proposed.

EFFECT: invention allows to obtain antibodies with high affinity and enhanced aggregation stability.

15 cl, 17 dwg, 6 tbl, 19 ex

Similar patents RU2609627C2

Title	Year	Author	Number
ANTI-IL-17 ANTIBODIES, METHODS OF THEIR PRODUCTION AND APPLICATION	2014	Ulitin Andrej Borisovich Evdokimov Stanislav Rudolfovich Solovev Valerij Vladimirovich Chernykh Julija Sergeevna Goncharova Olga Vladimirovna Korzhavin Dmitrij Valerevich Chernovskaja Tatjana Veniaminovna Ivanov Roman Alekseevich Morozov Dmitrij Valentinovich	RU2577228C2
TRISPECIFIC IL-17A, IL-17F AND OTHER PROINFLAMMATORY MOLECULES ANTIBODIES	2016	Morozov Dmitrij Valentinovich Ulitin Andrej Borisovich Zubareva Ekaterina Sergeevna Ustyugov Yakov Yurevich Karabelskij Aleksandr Vladimirovich Korzhavin Dmitrij Valerevich Chernovskaya Tatyana Veniaminovna Grachev Aleksandr Valerevich Basovskij Yurij Ivanovich Lomkova Ekaterina Aleksandrovna Usatova Veronika Sergeevna Aleksandrov Aleksej Aleksandrovich Morozova Elena Leonidovna Ivanov Roman Alekseevich Yakovlev Pavel Andreevich	RU2680011C2
MONOCLONAL ANTIBODY TO IL-5RΑ	2017	Pestova Natalya Evgenevna Krendeleva Elena Andreevna Solovyev Valery Vladimirovich Iakovlev Pavel Andreevich Shchemeleva Mariya Aleksandrovna Belyasnikova Alina Valerevna Vladimirova Anna Konstantinovna Legotskij Sergej Aleksandrovich Zhirivskaya Galina Stepanovna Sozonova Aleksandra Aleksandrovna Nemankin Timofey Aleksandrovich Doronin Aleksandr Nikolaevich Misorin Aleksej Konstantinovich Sofronova Ekaterina Vladimirovna	RU2698048C2
BISPECIFIC ANTI-HER2 / ANTI-HER3 ANTIBODIES	2016	Moskaleva Olga Vasilevna Ulitin Andrej Borisovich Solovev Valerij Vladimirovich Zaripova Dina Anvarovna Vladimirova Anna Konstantinovna Nemankin Timofej Aleksandrovich Shmakova Aleksandra Pavlovna Shitikova Viktoriya Olegovna Artyukhova Marina Vladimirovna Diduk Sergej Vasilevich Torokhin Andrej Alekseevich Krapivin Bogdan Nikolaevich Grachev Aleksandr Valerevich Ivanov Roman Alekseevich Morozov Dmitrij Valentinovich	RU2653443C2
ANTI-IL-17F ANTIBODIES AND METHODS FOR USE THEREOF	2010	Masternak Kshishtof Russo Fransua	RU2605318C2
AQUEOUS PHARMACEUTICAL COMPOSITION OF ANTI-IL17A ANTIBODY AND ITS APPLICATION	2019	Chernyaeva Ekaterina Valerevna Lomkova Ekaterina Aleksandrovna Artemeva Antonina Vasilevna Eremeeva Anna Viktorovna Ivanov Roman Alekseevich Ryakhovskaya Anastasiya Mikhajlovna Shitikova Viktoriya Olegovna Yakovlev Aleksandr Olegovich Morozov Dmitrij Valentinovich	RU2754760C2
ANTIBODY OR ITS ANTI-BINDING FRAGMENT, WHICH IS CAPABLE TO BE BOUND USING THE INTERLEUKIN-6 HUMAN RECEPTOR	2016	Evdokimov Stanislav Rudolfovich Ulitin Andrej Borisovich Solovev Valerij Vladimirovich Aleksandrov Aleksej Aleksandrovich Chernykh Yuliya Sergeevna Nemankin Timofej Aleksandrovich Vladimirova Anna Konstantinovna Smotrov Oleg Igorevich Chernovskaya Tatyana Veniaminovna Moshchenko Aleksandr Aleksandrovich Nalobina Viktoriya Evgenevna Ivanov Roman Alekseevich Morozov Dmitrij Valentinovich	RU2656160C2
ANTI-PD-1 ANTIBODIES, METHOD FOR THEIR PRODUCTION, AND METHOD OF APPLICATION	2016	Ekimova Viktoriya Mikhajlovna Korzhavin Dmitrij Valerevich Chernykh Yuliya Sergeevna Nemankin Timofej Aleksandrovich Solovev Valerij Vladimirovich Vladimirova Anna Konstantinovna Bulankina Irina Andreevna Diduk Sergej Vasilevich Goncharova Olga Vladimirovna Eroshova Anna Vladimirovna Ustyugov Yakov Yurevich Artyukhova Marina Vladimirovna Ulitin Andrej Borisovich Ivanov Roman Alekseevich Morozov Dmitrij Valentinovich	RU2656181C1
PROTEIN COMPLEXES CONTAINING SUPERHELIX AND/OR BANDING, AND THEIR USE	2010	Kristensen Ehrin Kh. Iton Dehn L. Vendel Ehndrju S. Vranik Bernd	RU2573915C2
DOUBLE SPECIFICITY ANTIBODIES	2014	Fuh Germaine Lee Chingwei V. Koenig Patrick	RU2732032C2

RU 2 609 627 C2

Authors

Ulitin Andrej Borisovich

Solovev Valerij Vladimirovich

Nemankin Timofej Aleksandrovich

Goncharova Olga Vladimirovna

Ekimova Viktoriya Mikhajlovna

Evdokimov Stanislav Rudolfovich

Chernykh Yuliya Sergeevna

Korzhavin Dmitrij Valerevich

Sofronova Ekaterina Vladimirovna

Chernovskaya Tatyana Veniaminovna

Ustyugov Yakov Yurevich

Ivanov Roman Alekseevich

Morozov Dmitrij Valentinovich

Dates

2017-02-02—Published

2014-09-26—Filed