FIELD: medicine.
SUBSTANCE: invention refers to new compounds chosen from the group 3-(2-mono- or dimethylaminomethylcyclohexyl)phenol, chosen of the group including mono-[3-(2-dimethylaminomethylcyclogexyl) phenyl]sulphate, mono-(1R,2R)-[3-(2-dimethylaminomethylcyclogexyl) phenyl]sulphate, 3-(2-methylaminomethylcyclogexyl)phenol, (1R,2R)-3-(2-methylaminomethylcyclogexyl)phenol, N-oxide 3-(2-dimethylaminomethylcyclogexyl)phenol, N-oxide (1R,2R)-3-(2-dimethylaminomethylcyclogexyl)phenol, 6-[3-(2-dimethylaminomethylcyclogexyl)phenoxy]-3,4,5-trihydroxytetrahydropyran-2-carboxylic acid, 6-[(1R,2R)-3-(2-dimethylaminomethylcyclogexyl)phenoxy]-3,4,5-trihydroxytetrahydropyran-2-carboxylic acid, 4-(2-dimethylaminomethylcyclogexyl)catechol, (1R,2R)-4-(2-dimethylaminomethylcyclogexyl)catechol, 3-(2-aminomethylcyclohexyl)phenol, (1R,2R)-3-(2-aminomethylcyclohexyl)phenol, C-[2-(3-methoxyphenyl)cyclogexyl]methylamine, (1R,2R)-C-[2-(3-methoxyphenyl)cyclogexyl]methylamine, [2-(3-methoxyphenyl) cyclohexylmethyl]methylamine, (1R,2R)-[2-(3-methoxyphenyl) cyclohexylmethyl]methylamine, N-oxide [2-(3-methoxyphenyl)cyclohexylmethyl]dimethylamine, and N-oxide (1R,2R)-[2-(3-methoxyphenyl)cyclohexylmethyl]dimethylamine, and also to application of the compounds for preparing a drug for treatment of depression which can be combined with pain, first of all acute visceral chronic or nephropathic pain and pain caused by cancer.
EFFECT: improved clinical effectiveness.
6 cl, 3 dwg, 2 tbl, 14 ex
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