FIELD: medicine, pharmaceutics.
SUBSTANCE: dosage form for pain management and controlled release of 3-(2-dimethylaminomethylcyclohexyl)phenol or one of its pharmaceutically acceptable salts contains said active substance and a polymer matrix of cellulose ether, which has a viscosity ranging within 3000 to 150000 mPa·s in the concentration of 2.0 wt % in a water solution at 20°C. Cellulose ether is selected from a group consisting of methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and hydroxypropyl methylcellulose. The dosage form ensures in vivo a maximum plasma level of the active substance in 2-10 h.
EFFECT: dosage form under the invention provides maintaining the plasma concentration of the active substance 3-(2-dimethylaminomethylcyclohexyl)phenol at a pharmacologically effective level for at least 12 h and shows minimum spectrum of side effects including nausea and/or vomiting.
35 cl, 1 dwg, 8 ex
