FIELD: medicine, pharmaceutics.
SUBSTANCE: invention proposes application of (1R)-1-[({(2R)-2-amino-3-[(8S)-8-(cyclohexyl-methyl)-2-phenyl-5.6-dihydromidazo[1.2-a]pyrazin-7(8H)-yl]-3-oxopropyl}ditio)methyl]-2-[(8S)-8-(cyclohexylmethyl)-2-phenyl-5.6-dihydromidazo[1,2-a]pyrazin-7(8H)-yl]-2-oxoethylamine and pharmaceutically acceptable salts thereof for obtaining a remedy for pain prevention or management. In particular, pains provoked by neuropathy and/or inflammation, other chronic diseases: cancer, radiculopathies, painful obesity, migraine, chronic diseases, fibromailgia, algoneurodistrophy, or complex local pain syndrome, brain vascular diseases, arthrosis, arthritis, diabetic neuropathies or neuropathies due to HIV, sciatica, painful muscle contractions, intoxication, scalds, posthepeic neuralgias, thalamus disease or disseminated sclerosis, or pre- and/or postsurgical pains.
EFFECT: reduction of pain sensitivity threshold at hyperalgesia and at taxol induced neuropathy.
7 cl, 4 dwg, 3 ex
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