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2 388 752

(13)

(51)

IPC

C07D223/16(2006-01-01)

C07D413/14(2006-01-01)

C07D401/12(2006-01-01)

C07D417/14(2006-01-01)

C07D405/14(2006-01-01)

C07D417/12(2006-01-01)

C07D409/14(2006-01-01)

C07D471/04(2006-01-01)

C07D401/14(2006-01-01)

C07D491/04(2006-01-01)

C07D403/12(2006-01-01)

C07D403/14(2006-01-01)

A61K31/55(2006-01-01)

(21) (22)

Application

2005122932/04, 2003-12-18

(24)

Start date

2003-12-18

(22)

Actual filing date

2003-12-18

(45)

Published

2010-05-10

(72)

Inventor

Bamford Mark DzhejmsDin Dehvid KennetSekhmi Sandzhit SingkhUilson Dehvid Mehtt'JuVizerington Dzhejson

(73)

Holder

Glehkso Grup Limited

(3-CYCLOALKYL-2, 3, 4, 5 - TETRAHYDRO-1H-BENZO [d] AZEPIN-7-YLOXY) DERIVATIVES, USE THEREOF FOR INHIBITING H3 RECEPTORS, PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD Russian patent published in 2010 - IPC C07D223/16 C07D413/14 C07D401/12 C07D417/14 C07D405/14 C07D417/12 C07D409/14 C07D471/04 C07D401/14 C07D491/04 C07D403/12 C07D403/14 A61K31/55

Abstract RU 2388752 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to benzazepin derivatives of formula (I), where R¹ is unsubstituted cyclobutyl, R² is 3-pyrazinyl, substituted CON(H)(Me) or 2-pyridinyl-M-pyrrolidinyl, where the said pyrrolidinyl group is substituted with a =O group; which is: methylamide 5-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy) pyrazine-2-carboxylic acid

or 1-{6-[(3-cyclbutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-pyridinyl}-2-pyrrolidinone

EFFECT: obtaining compounds which have affinity to histamine H3 receptor and pharmaceutical compositons containing said compounds.

11 cl, 288 ex

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RU 2 388 752 C2

Authors

Bamford Mark Dzhejms

Din Dehvid Kennet

Sekhmi Sandzhit Singkh

Uilson Dehvid Mehtt'Ju

Vizerington Dzhejson

Dates

2010-05-10—Published

2003-12-18—Filed