FIELD: biotechnologies.
SUBSTANCE: device generates one specific and selective signal, which has sinusoid configuration of wave and when applied to electrodes, coils or other field-generating devices, it results in generation of electric field, having amplitude of approximately 20 mV/cm in bone tissue at 60 kHz with approximately 50% cyclic mode. Specified electric field is specific and selective for activation of bone morphogenetic protein (BMP) gene expression measured by messenger RNA in specified bone tissue.
EFFECT: efficient treatment of bone fracture, prevention of fracture risk, slow knitting, non-unions, bone defects, arthrodesis of vertebrae, osteonecrosis and osteoporosis.
6 cl, 8 dwg, 1 ex
| Title |
Year |
Author |
Number |
| BONE LOSS TREATMENT AND PREVENTION METHOD |
2007 |
- Allard Dzhon Dejvid
- Klejn Robert Frederik
- Peltz Gehri Allen
|
RU2358728C2 |
| GENE-THERAPY DNA-VECTOR BASED ON GENE-THERAPY DNA-VECTOR VTVAF17, CARRYING TARGET GENE SELECTED FROM GROUP OF GENES BMP-2, BMP-7, LMP-1, NELL-1 TO INCREASE EXPRESSION LEVEL OF THESE TARGET GENES, METHOD FOR PRODUCTION AND APPLICATION THEREOF, STRAIN ESCHERICHIA COLI SCS110-AF/VTVAF17-BMP-2, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-BMP-7, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-LMP-1, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-NELL-1, CARRYING GENE-THERAPY DNA VECTOR, METHOD FOR PRODUCTION THEREOF, METHOD FOR INDUSTRIAL PRODUCTION OF GENE-THERAPY DNA VECTOR |
2018 |
|
RU2720521C1 |
| COMPOSITIONS AND METHODS OF TREATING MPS1 |
2014 |
- Uilson Dzhejms M.
- Gurda Brittni L.
|
RU2708318C2 |
| ERYTHROFERRONE AND ERFE POLYPEPTIDES AND METHODS FOR REGULATING IRON METABOLISM |
2013 |
- Ganz Tomas
- Nemet Elizabeta
- Kautts Leon
|
RU2684216C2 |
| METHODS AND COMPONENTS FOR INDUCTION OF TUMOR- -SPECIFIC CYTOTOXICITY |
1998 |
- Khokhberg Abrakham
- Ajesh Sukhail
|
RU2214280C2 |
| INTERFERON PRODRUG FOR CANCER TREATMENT |
2018 |
|
RU2788736C2 |
| METHODS FOR BONE CANCER RELATED PAIN MANAGEMENT BY ADMINISTRATION OF NERVE GROWTH FACTOR ANTAGONIST |
2005 |
- Shelton Dehvid L.
- Mantikh Patrik Uill'Jam
|
RU2389509C2 |
| MORPHOGENE BONE PROTEINS (BMP), BMP RECEPTORS AND BINDING BMP PROTEINS AND THEIR APPLICATION FOR DIAGNOSTICS AND GLAUCOMA TREATMENT |
2002 |
- Klark Ehbbot F.
- Uordinger Robert Dzh.
|
RU2336902C2 |
| TRANSIENT CELLULAR REPROGRAMMING TO REVERSE CELL AGING |
2019 |
- Sebastiano, Vittorio
- Sarkar, Tapash Jay
|
RU2801316C2 |
| FACTOR EFFECTING ON ACTIVITY OF TUMOR NECROSIS FACTOR RECEPTOR-RELEASING ENZYME |
1999 |
- Gatanaga Tetsuja
- Grehndzher Gejl A.
|
RU2279478C2 |
