FIELD: biotechnology.
SUBSTANCE: invention relates to the methods of treating a somatic cell, including exposing the somatic cell to messenger RNA (mRNA) encoding one or more cellular reprogramming factors, which results in a rejuvenated cell while maintaining cellular identity. The methods and compositions useful for intracellular rejuvenation, tissue engineering, and regenerative medicine are provided herein.
EFFECT: compositions and methods of rejuvenation of old cells and tissues with restoration of functionality are disclosed.
32 cl, 11 dwg
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