FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry, specifically to a method of synthesising 2-alkyl-5,6,7,8,9,10-hexahydro-4H-cyclonone[b]selenophenes, which involves reaction of an equimolar mixture of cyclonone-1,2-diene and alka-1,2-diene (octa-1,2-diene, deca-1,2-diene, dodeca-1,2-diene) with EtMgBr in the presence of magnesium and a titanocene dichloride catalyst in an argon atmosphere at room temperature in diethyl ether for 2-4 hours with subsequent addition of Se in equimolar ratio to the EtMgBr amount and heating the reaction mass for 5 hours at approximately 40°C in benzene, and then for 1 hour at approximately 140°C.
EFFECT: obtained bicyclic selenophenes can be used in organic synthesis, as well as obtaining biologically active heterocyclic compounds.
1 cl, 1 ex, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING 2-ALKYL-5,6,7,8,9,10-HEXAHYDRO-4H-CYCLONONE [b]THIOPHENES | 2008 |
|
RU2382776C1 |
| 1, 2, 3, 4, 5, 6, 10, 11, 12, 13, 14, 15, 15a, 15b-TETRADECAHYDRODICYCLONONE[b,d]SELENOPHENE SYNTHESIS METHOD | 2008 |
|
RU2401835C2 |
| METHOD FOR SYNTHESIS OF 1,2,3,4,5,6,10,11,12,13,14,15,15a,15b-TETRADECAHYDRODICYCLONONE [b, d] SELENOPHENE | 2008 |
|
RU2383538C1 |
| 1,2,3,4,5,6,10,11,12,13,14,15,15a,15b-TETRADECAHYDRO-DICYCLONONE[b,d]THIOPHENE SYNTHESIS METHOD | 2008 |
|
RU2398772C2 |
| METHOD OF PRODUCING 1,2,3,4,5,6,7,9,10,11,12,13,14,15-TETRADECAHYDRODICYCLONONE[b,d]THIOPHENE | 2008 |
|
RU2382775C1 |
| METHOD OF PRODUCING 11,12-DIALKYL-10-MAGNESABICYCLO[7.3.0]DODECA-8,11-DIENES | 2007 |
|
RU2349594C1 |
| METHOD OF PRODUCING 3-ALKYLIDENE-4-MAGNESABICYCLO[7.3.0]DODEC-5-ENES | 2008 |
|
RU2375365C2 |
| METHOD OF OBTAINING 10,11-DIALKYL-9-MAGNESABICYCLO[6,3,0]UNDECA-1(8),10-DIENES | 2007 |
|
RU2355695C2 |
| METHOD OF OBTAINING 10-ETHYL-11,12-DIALKYL-10-ALUMINABICYCLO [7,3,0]DODECA-8,11-DIENES | 2007 |
|
RU2348640C1 |
| 1,2,3,4,5,6,7,9,10,11,12,13,14,15-TETRADECAHYDRO-DICYCLONONE[b,d]THIOPHENE SYNTHESIS METHOD | 2008 |
|
RU2402542C2 |
