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2 401 835

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IPC

C07D345/00(2006-01-01)

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Application

2008134294/04, 2008-08-20

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Start date

2008-08-20

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Actual filing date

2008-08-20

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Published

2010-10-20

(72)

Inventor

Dzhemilev Usein MemetovichD'Jakonov Vladimir Anatol'EvichMakarov Aleksej AleksandrovichIbragimov Askhat GabdrakhmanovichPopod'Ko Natal'Ja RomanovnaDzhemileva Galina Arkad'Evna

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Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Neftekhimii I Kataliza Ran

1, 2, 3, 4, 5, 6, 10, 11, 12, 13, 14, 15, 15a, 15b-TETRADECAHYDRODICYCLONONE[b,d]SELENOPHENE SYNTHESIS METHOD Russian patent published in 2010 - IPC C07D345/00

Abstract RU 2401835 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to a method for synthesis of 1,2,3,4,5,6,10,11,12,13,14,15,15a,15b-tetradecahydrodicyclonone[b,d]selenophene of general formula (1) . The method involves reaction of cyclonone-1,2-diene with ethylmagnesiumbromide (EtMgBr/ether) in the presence of Mg (powder) and a titanocene dichloride (Cp₂TiCl₂) catalyst taken in molar ratio cyclonone-1,2-diene : EtMgBr : Mg : Cp₂TiCl₂ = 20:(22-26):20:(1.0-1.4), preferably 20:24:20:1.2. The reaction takes place in an argon atmosphere at room temperature (20-22°C) and atmospheric pressure for 6-8 hours in diethyl ether, with subsequent addition of an amount of selenium (Se) which is equimolar to EtMgBr, benzene as a solvent and heating the reaction mass for 5 hours at temperature of approximately 40°C.

EFFECT: obtained compound can be used in fine organic synthesis, as well as obtaining biologically active heterocyclic compounds.

1 ex, 1 tbl

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RU 2 401 835 C2

Authors

Dzhemilev Usein Memetovich

D'Jakonov Vladimir Anatol'Evich

Makarov Aleksej Aleksandrovich

Ibragimov Askhat Gabdrakhmanovich

Popod'Ko Natal'Ja Romanovna

Dzhemileva Galina Arkad'Evna

Dates

2010-10-20—Published

2008-08-20—Filed