METHOD FOR PREPARING DRUG BASED ON HIGHER AFFINITY OF ACTIVE AGENTS TO CRYSTALLINE MICROPARTICLE SURFACES Russian patent published in 2010 - IPC A61J3/00 A61K9/16 A61K38/00 A61K47/22 

FIELD: medicine.

SUBSTANCE: invention refers to methods for adsorption of an active agent representing protein or peptide, on a surface in a pre-formed crystalline diketopiperasine microparticles which includes the stage: modifying of chemical potential of the active agent which provides energy-favourable reaction of the active agent and the diketopiperasine microparticle and does not include solvent removal, and the stage of adsorption of the active agent on a surface of the pre-formed crystalline diketopiperasine microparticle. The modifying stage of chemical potential includes change of the solution medium by adding a modifier of the active agent to the solution.

EFFECT: higher adsorption of the active agent on the surfaces of the microparticle with reduced tendency to remain in the solution.

31 cl, 17 dwg, 7 ex