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2 391 347

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(51)

IPC

C07F5/00(2006-01-01)

A61K49/06(2006-01-01)

(21) (22)

Application

2008142157/04, 2008-10-23

(24)

Start date

2008-10-23

(22)

Actual filing date

2008-10-23

(45)

Published

2010-06-10

(72)

Inventor

Amirov Rustehm Rafaehl'EvichZijatdinova Anna BulatovnaSaprykova Zoja Afanas'EvnaAntipin Igor' SergeevichStojkov Ivan IvanovichZhukov Arkadij Jur'Evich

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Universitet Im. V.I. Ul'Janova-Lenina"

HIGH-RELAXIVITY GADOLINIUM COMPLEXES Russian patent published in 2010 - IPC C07F5/00 A61K49/06

Abstract RU 2391347 C1

FIELD: chemistry.

SUBSTANCE: invention relates to high-relaxivity solutions of gadolinium complexes for making compositions used as contrast media for magnetic resonance tomography. The composition is obtained by mixing solutions of simple gadolinium salt and a ligand in form of stereoisomers of cone and partial cone derivatives of thiacalix[4]arene of formula (where X is n-tert-butyl radical, R is a chelating substitute from CH₂COO^-, -CH₂CONHCH₂COO^-,-CH₂CON(CH₂COO^-)2). If necessary, the solution may contain a nonionic surfactant.

EFFECT: invention enables to obtain a gadolinium complex with high relaxation efficiency.

1 cl, 1 tbl, 4 dwg

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RU 2 391 347 C1

Authors

Amirov Rustehm Rafaehl'Evich

Zijatdinova Anna Bulatovna

Saprykova Zoja Afanas'Evna

Antipin Igor' Sergeevich

Stojkov Ivan Ivanovich

Zhukov Arkadij Jur'Evich

Dates

2010-06-10—Published

2008-10-23—Filed