MAGNETIC RESONANT AND RADIOPAQUE CONTRAST AGENT BASED ON COMPLEX FERRIC OXIDE AND METHOD FOR PRODUCING THEREOF Russian patent published in 2011 - IPC A61K49/04 A61K49/18 B82B1/00 B82B3/00 

FIELD: medicine.

SUBSTANCE: invention refers to a magnetic resonant and radiopaque diagnostic agent for magnetic resonant tomography (MRT) and X-ray computed tomography (XRCT). Said agent represents complex ferric oxide in a physiologically acceptable carrier which in addition contains citric acid 2.4 mg/l for particle size stabilisation of complex ferric oxide within the range 5-10 nm and sodium citrate 190 mg/ml for compositional stabilisation of the radiopaque agent; the concentration of complex ferric oxide makes 600 mg/ml, while the concentration of water for injections is 460 mg/ml. Also, the invention concerns a method for producing a radiopaque contrast agent which consists in mixing ferric salts, adding ammonium hydrate and citric acid, and then adding water-dissolved sodium citrate with mixing up and further cooling and filtering of undissolved sodium citrate.

EFFECT: invention provides higher diagnostic efficiency, reliable diagnostic data, lower concentration of the introduced contrast agent.

4 cl, 3 dwg