FIELD: chemistry; biochemistry.
SUBSTANCE: invention relates to biotechnology, in particular to obtaining protein complexes and can be used in medicine. A complex of biologically active recombinant protein is obtained, which is non-covalently bonded to polysialic acid which is inactive in aqueous solution at pH 4.4-4.7 which has prolonged therapeutic effect and has general formula:
where m=20-110; n=1-4; P is biologically active recombinant protein.
EFFECT: invention enables to obtain a complex of biologically active recombinant protein with polysialic acid, having stability and prolonged effect.
6 dwg, 2 tbl, 15 ex
| Title |
Year |
Author |
Number |
| HUMAN OXYNTOMODULIN, ITS APPLICATION, MEDICATION BASED THEREON AND METHOD OF APPLYING MEDICATION FOR TREATMENT AND PREVENTION OF HYPERGLYCEMIA |
2009 |
- Esipov Roman Stanislavovich
- Stepanenko Vasilij Nikolaevich
- Bejrakhova Ksenija Andreevna
- Miroshnikov Anatolij Ivanovich
- Avtushenko Sergej Sergeevich
- Surkov Kirill Gennadievich
- Romanov Vadim Dmitrievich
- Genkin Dmitrij Dmitrievich
|
RU2524204C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING Fc-REGION OF IMMUNOGLOBULIN AS CARRIER |
2004 |
- Kim Jang Min
- Song Dae Khae
- Dzung Sung Joub
- Kim Chang Khvan
- Choi In Jang
- Kvon Se Chang
- Li Gvan Sun
|
RU2352583C2 |
| METHOD OF PRODUCING MONO CONJUGATE OF POLYSIALIC ACID WITH THYMOSIN BETA 4 AND COVALENT MONO CONJUGATE OF POLYSIALIC ACID WITH THYMOSIN BETA 4, RESISTANT TO DEGRADATION IN A BLOOD FLOW |
2015 |
- Esipov Roman Stanislavovich
- Makarov Dmitrij Aleksandrovich
- Stepanenko Vasilij Nikolaevich
- Miroshnikov Anatolij Ivanovich
|
RU2605385C2 |
| N-TAILED POLYSIALYLATION |
2007 |
- Dzhajn Sanzhaj
- Chzhan Zhunshen
|
RU2432175C2 |
| METHOD OF POLYSIALYLATED HUMAN INSULIN PURIFICATION |
2015 |
- Avtushenko Sergej Sergeevich
- Surkov Kirill Gennadievich
- Petrov Andrej Valerevich
- Yan Sergej Fedorovich
- Lazarev Vyacheslav Sergeevich
- Gavrilova Evgeniya Nikolaevna
|
RU2736358C2 |
| ALDEHYDE DERIVATIVES OF SIALIC ACID, METHODS OF THEIR OBTAINMENT, CONJUGATES OF ALDEHYDE DERIVATIVES OF SIALIC ACID, AND PHARMACEUTICAL COMPOSITION BASED ON THEM |
2004 |
- Dzhain Sandzhaj
- Lejng Piter
- Gregoriadis Gregori
- Khrechuk-Kherst Dejl Govard
- Papaioannu Ioannis
|
RU2333223C2 |
| NEW FUNCTIONAL, HIGH-PURITY STABLE CONJUGATE OF GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF) AND POLYETHYLENE GLYCOL WITH PROLONGED BIOLOGICAL ACTION, APPLICABLE FOR MEDICAL PURPOSES, AND BASED IMMUNOBIOLOGICAL AGENT |
2010 |
- Chernovskaja Tat'Jana Veniaminovna
- Rudenko Elena Georgievna
- Denisov Lev Aleksandrovich
- Morozova Elena Leonidovna
- Morozov Dmitrij Valentinovich
|
RU2446173C1 |
| PEG-MODIFIED HUMAN INTERFERON β-1a MOLECULE WITH ANTIVIRAL, IMMUNOMODULATORY AND ANTIPROLIFERATIVE ACTIVITY, WITH IMPROVED STABILITY, REDUCED IMMUNOGENICITY, IMPROVED PHARMACOKINETIC AND PHARMACODYNAMIC PARAMETERS, SUITABLE FOR MEDICAL USE, AND IMMUNOBIOLOGICAL FORMULATION BASED THEREON |
2013 |
- Chernovskaja Tat'Jana Veniaminovna
- Efanov Jurij Georgievich
- Morozov Dmitrij Valentinovich
- Rudenko Elena Georgievna
- Korzhavin Dmitrij Valer'Evich
- Ustjugov Jakov Jur'Evich
- Ivanov Roman Alekseevich
|
RU2576372C2 |
| RECOMBINANT PLASMID DNA pHINS11 CODING HYBRID PROTEIN-HUMAN INSULIN PRECURSOR, Escherichia coli CELL, TRANSFORMED WITH RECOMBINANT PLASMID DNA pHINS11, Escherichia coli BACTERIA STRAIN JM109/pHINS11 - PRODUCER OF HYBRID PROTEIN-HUMAN INSULIN PRECURSOR, AND METHOD OF OBTAINING HUMAN INSULIN |
2006 |
- Shmatchenko Vadim Vasil'Evich
- Shmatchenko Natal'Ja Anatol'Evna
- Bajdus' Aleksandr Nikolaevich
- Kuptsov Vasilij Nikolaevich
- Nozdrin Viktor Nikolaevich
- Stepanov Aleksej Vjacheslavovich
|
RU2354702C2 |
| RECOMBINANT PLASMID DNA pHIG05, CODING HYBRID PROTEIN WITH HUMAN PROINSULIN Glargine, CELL Escherichia coli, TRANSFORMED BY RECOMBINANT PLASMID DNA PHIG05, AND STRAIN OF BACTERIA Escherichia coli JM109/pHIG05-PRODUCENT OF HYBRID PROTEIN WITH HUMAN PROINSULIN Glargine |
2013 |
- Shmatchenko Vadim Vasil'Evich
- Sadgjan Armen Sergeevich
|
RU2515115C1 |
