FIELD: biotechnology.
SUBSTANCE: group of inventions relates to biotechnology and can be used in medicine and pharmaceutical industry. Developed method for regioselective chemical N-terminal sialylation thymosin beta 4. By using of above method is obtained mono conjugate of polysialic acid with thymosin beta 4, with improved pharmacokinetic properties. Confirmed modification of N-terminal alpha-amino group of thymosin beta 4.
EFFECT: using the group of inventions allows to obtain mono sialylated thymosin beta 4, having prolonged stability in blood flow, with high output.
2 cl, 4 dwg, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COVALENT MONOKONJUGAT OF HEXANOIC ACID WITH THYMOSIN BETA 4, RESISTANT TO DEGRADATION IN A STREAM OF BLOOD, AND METHOD FOR PRODUCTION THEREOF | 2015 |
|
RU2604686C2 |
| COVALENT MONOCONJUGATE OF POLYETHYLENE GLYCOL WITH THYMOSIN BETA 4, RESISTANT TO DEGRADATION IN BLOODSTREAM AND METHOD FOR ITS PRODUCTION | 2015 |
|
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| SITE-SPECIFIC INSULIN CONJUGATE | 2014 |
|
RU2677800C2 |
| NEW FUNCTIONAL, HIGH-PURITY STABLE CONJUGATE OF GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF) AND POLYETHYLENE GLYCOL WITH PROLONGED BIOLOGICAL ACTION, APPLICABLE FOR MEDICAL PURPOSES, AND BASED IMMUNOBIOLOGICAL AGENT | 2010 |
|
RU2446173C1 |
| HUMAN OXYNTOMODULIN, ITS APPLICATION, MEDICATION BASED THEREON AND METHOD OF APPLYING MEDICATION FOR TREATMENT AND PREVENTION OF HYPERGLYCEMIA | 2009 |
|
RU2524204C2 |
| COMPLEX OF BIOLOGICALLY ACTIVE RECOMBINANT PROTEIN WITH POLYSIALIC ACID | 2008 |
|
RU2391354C1 |
| NOVEL FUNCTIONALLY ACTIVE, HIGHLY PURE, STABLE CONJUGATE OF INTERFERON α WITH POLYETHYLENE GLYCOL, REPRESENTED BY ONE PEG- NH-IFN POSITIONAL ISOMER, WITH IMPROVED IMMUNOGENICITY, WITH PROLONGED BIOLOGICAL ACTION, SUITABLE FOR MEDICAL APPLICATION, AND IMMUNOLOGICAL AGENT BASED THEREON | 2010 |
|
RU2447083C1 |
| INSULIN CONJUGATE WITH APPLICATION OF IMMUNOGLOBULIN FRAGMENT | 2011 |
|
RU2519073C1 |
| ALDEHYDE DERIVATIVES OF SIALIC ACID, METHODS OF THEIR OBTAINMENT, CONJUGATES OF ALDEHYDE DERIVATIVES OF SIALIC ACID, AND PHARMACEUTICAL COMPOSITION BASED ON THEM | 2004 |
|
RU2333223C2 |
| EXTENDED FACTOR OF HUMAN ERYTHROPOIESIS AND A THERAPEUTIC AGENT BASED THEREON | 2015 |
|
RU2664588C2 |
