HIGH PRESSURE FINAL STERILISATION OF PHARMACEUTIC PREPARATIONS AND MEDICAL PRODUCTS Russian patent published in 2010 - IPC A61L2/02 

FIELD: medicine.

SUBSTANCE: invention belongs to sterilisation of pharmaceutic preparations in form of small particles or droplets dispersion and can be used in pharmaceutic industry. Sterilisation method of dynamic dispersion system which may have stable and unstable state includes impact of pressure higher than 0.25 MPa on small particles or droplets system for heating system to temperature higher than 100 °C during enough time for system's sterilisation, and system's decompression before it passes in unstable state. Invention refers to systems of dispersed micro- and nanoparticles in form of small particles or droplets which may have stable and unstable state. Particles or droplets of dispersion system include pharmaceutically active compound connected to excipient including superficially active compound.

EFFECT: invention provides stabilising of pharmaceutically active compound and excipient associates in form of dispersion system of particles or droplets in process of sterilisation at higher temperatures.

37 cl, 25 dwg, 1 tbl, 1 ex