FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to surface-modified particles, and methods for preparing and using, pharmaceutical suspensions containing said surface-modified particles, and a method for enhancing the active agent internalisation. The surface-modified particles comprise a particle core and a coating coupled with the particle core; the above coating is absorbed on the surface of the particle core wherein the particle core contains a therapeutic agent; the coating contains opsonin, and the surface-modified particle has an average particle size from approximately 1 nm to 2000 nm, and said opsonin is specified in proteins and peptides which bind to the particles or cells so that the phagocytosis ability of the particles or cells increases, wherein pH of the opsonin solution is below an isoelectric point of opsonin.
EFFECT: developing the method for enhancing the active agent internalisation.
35 cl, 11 dwg, 3 tbl, 11 ex
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