METHOD OF INDUCING TERMINAL DIFFERENTIATION Russian patent published in 2010 - IPC C07C237/04 C07C231/00 

Abstract RU 2394022 C2

FIELD: chemistry; pharmaceutics.

SUBSTANCE: present invention relates to a solid pharmaceutical composition for treating malignant tumours, including malignant tumours in the larynx, thyroid gland, perspiratory glands, kidneys, prostate gland, Hodgkin's disease, non-Hodgkin's lymphoma and leucosis, containing an effective amount of the crystalline form of suberoylanilide hydroxamic acid (SAHA), obtained through a method which involves recystallisation of an unrefined SAHA preparation from a mixture of methanol and water in ratio of approximately 2:1, and a carrier.

EFFECT: obtaining a solid pharmaceutical composition for treating malignant tumours.

9 cl, 20 tbl, 14 dwg, 7 ex

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RU 2 394 022 C2

Authors

Richon Viktorija M.

Chao Kh. Dzhudi

Miller Tomas A.

Kelli V. Kevin

Dates

2010-07-10Published

2003-03-04Filed