COMBINATION OF A HISTONE DEACETYLASE INHIBITOR AND A PROTEIN KINASE INHIBITOR AND PHARMACEUTICAL APPLICATION THEREOF Russian patent published in 2022 - IPC A61K31/4406 A61K31/47 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to an application of a combination of a histone deacetylase inhibitor and a protein kinase inhibitor in the production of a medicinal product for treating or preventing a tumour, wherein the histone deacetylase inhibitor is chidamide or a pharmacologically acceptable salt thereof, the protein kinase inhibitor is chiauranib or a pharmacologically acceptable salt thereof, and the tumour constitutes hepatic carcinoma, wherein the mass ratio of the histone deacetylase inhibitor and the protein kinase inhibitor is 5 to 60 mg as calculated for chidamide:10 to 100 mg as calculated for chiauranib, as well as to a pharmaceutical composition and a kit for treating hepatic carcinoma including such a combination.

EFFECT: production of a medicinal product for treating hepatic carcinoma by a combination of a histone deacetylase inhibitor chidamide and a protein kinase inhibitor chiauranib, exhibiting a synergistic anti-tumour effect.

8 cl, 6 dwg, 11 ex