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2 394 559

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IPC

A61K31/165(2006-01-01)

G09B23/28(2006-01-01)

A61K38/21(2006-01-01)

A61K31/536(2006-01-01)

A61P31/04(2006-01-01)

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Application

2008102621/14, 2008-01-28

(24)

Start date

2008-01-28

(22)

Actual filing date

2008-01-28

(45)

Published

2010-07-20

(72)

Inventor

Aleshkin Vladimir AndrianovichLapin Boris Arkad'EvichAfanas'Ev Stanislav StepanovichDzhikidze Ehteri KapitonovaSimavonjan Kajtsak VartanovichRubal'Skij Oleg Vasil'EvichVoropaeva Elena AleksandrovnaDavydkin Valerij Jur'EvichDavydkin Igor' Jur'EvichKholodilova Ljubov' IvanovnaMelikhova Aleksandra VadimovnaKebu Tat'Jana IvanovnaBajrakova Aleksandra L'VovnaAfanas'Ev Maksim StanislavovichEgorova Tat'Jana PetrovnaRubal'Skij Evgenij OlegovichGolikova Tat'Jana OlegovnaEgorova Ekaterina AleksandrovnaKurakova Anna Alekseevna

(73)

Holder

Federal'Noe Gosudarstvennoe Uchrezhdenie Nauki Nauchno-Issledovatel'Skij Institut Ehpidemiologii I Mikrobiologii Imeni G.N. Gabrichevskogo Federal'Noj Sluzhby Po Nadzoru V Sfere Zashchity Prav Potrebitelej I Blagopoluchija Cheloveka" Mniiehm Im. G.N. Gabrichevskogo Rospotrebnadzora") Gosudarstvennoe Uchrezhdenie Institut Meditsinskoj Primatologii Rossijskoj Akademii Meditsinskikh Nauk" Nii Mp Ramn)Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennaja Meditsinskaja Akademija Federal'Nogo Agentstva Po Zdravookhraneniju I Sotsial'Nomu Razvitiju" Vpo Agma Roszdrava)

METHOD OF DETERMINING NON-SPECIFIC ANTI-INFECTIOUS ACTION OF IMMUNOMODELLING IMMUNOBIOLOGICAL PREPARATION Russian patent published in 2010 - IPC A61K31/165 G09B23/28 A61K38/21 A61K31/536 A61P31/04

Abstract RU 2394559 C2

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to treatment of infectious diseases, and can be used in determination of non-specific anti-infectious action of immunomodelling immunobiological preparation (IIP). Essence of method consists in the following: IIP in therapeutically efficient for immunocorrection day dose is perorally introduced to a group of 5-7 monkeys with diarrhea syndrome, in combination with efficient in case of diarrhea syndrome antibiotic, in day dose, which constitutes 1/2 of the dose efficient in case of diarrhea syndrome. After that in case if carried out treatment is inefficient during 2 days, day dose of antibiotic is increased to 3/4 of the dose efficient in case of diarrhea syndrome. Determined is either absence of non-specific anti-infectious IIP action in case when combined application of IIP and antibiotic proves to be inefficient during 7 days, or presence of non-specific anti-infectious IIP action in case when combined application of IIP and antibiotic proves to be efficient.

EFFECT: method allows to determine non-specific anti-infectious IIP action due to determination of minimal efficient in case of diarrhea syndrome day dose of antibiotic in its combination with IIP

3 ex

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RU 2 394 559 C2

Authors

Aleshkin Vladimir Andrianovich

Lapin Boris Arkad'Evich

Afanas'Ev Stanislav Stepanovich

Dzhikidze Ehteri Kapitonova

Simavonjan Kajtsak Vartanovich

Rubal'Skij Oleg Vasil'Evich

Voropaeva Elena Aleksandrovna

Davydkin Valerij Jur'Evich

Davydkin Igor' Jur'Evich

Kholodilova Ljubov' Ivanovna

Melikhova Aleksandra Vadimovna

Kebu Tat'Jana Ivanovna

Bajrakova Aleksandra L'Vovna

Afanas'Ev Maksim Stanislavovich

Egorova Tat'Jana Petrovna

Rubal'Skij Evgenij Olegovich

Golikova Tat'Jana Olegovna

Egorova Ekaterina Aleksandrovna

Kurakova Anna Alekseevna

Dates

2010-07-20—Published

2008-01-28—Filed