ANTIVIRAL AND ANTIMICROBIAL COMPOSITION Russian patent published in 2012 - IPC A61K38/21 A61K47/30 A61P31/12 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry. A composition represents a powder containing a substance comprising recombinant human interferon-α and target additives able to form a stable foam structure, specified in: polyethylene glycol, albumin, gelatine, pectin, casein, caseinate, casein hydrolysate, hydroxypropyl cellulose, polyglucin, dextrin, tragacanth, aerosil, mannitol or their mixtures; it is characterised by porous structure and fragility, has a relative disintegration shrinkage at least 10 %, equivalent pore diameter 10-110 mcm at particle size no more than 100 mcm and a resting angle less than 50° and represented in the form of a solid capsule in the following proportions in 1.0 g of the composition: human recombinant interferon-α - 10000-3000000 IU; target additives - the rest with the capsule coated with a layer of a enterosoluble substance specified in: shellac, oleic acid, hydroxypropyl cellulose, cellulose acetate phthalate, bee wax, Tween-20, Tween-80, castor oil, polyethylene oxide or their mixture. The maximum isotropic filling of the preset volume of the solid capsules ensures precise dosages of recombinant human interferon-α.

EFFECT: invention provides the isotropic filling of the 100% preset volume of the solid capsules.

4 cl, 4 ex