PEPTIDE HAVING NEUROTROPIC ACTIVITY Russian patent published in 2010 - IPC C07K5/10 A61K38/08 A61P25/28 

Abstract RU 2394836 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to bioorganic chemistry and medicine and can be used to prepare medicinal agents with neurotropic activity. The technical result is achieved due to creation of a peptide with neurotropic activity and having general formula: Ac-X-Met-Pro-Arg-Gly-NH2, where X-Met - L-Met or DL-Met.

EFFECT: obtaining a novel compound - analogues of the C-terminal end of vasopressin which are capable of selectively bonding with different subtypes of vasopressin receptors and, as a result, have different types of neurotropic activity, have low toxicity and are suitable for simple intranasal administration.

5 ex

Similar patents RU2394836C2

Title Year Author Number
NEUROPEPTIDES SHOWING BEHAVIORAL ACTIVITY 1989
  • Martinovich V.P.
  • Golubovich V.P.
  • Titov S.A.
  • Voskresenskaja O.G.
  • Ashmarin I.P.
  • Slobodchikova L.K.
  • Osipovich I.N.
  • Akhrem A.A.
SU1623166A1
PROTECTED DERIVATIVES OF VASOPRESSIN 1997
  • Samukov V.V.
  • Pozdnjakov P.I.
  • Sabirov A.N.
RU2123498C1
HEPTAPEPTIDE POSSESSING PROPERTIES OF PSYCHOSTIMULATOR OF PROLONGED ACTION WITH IMMUNOTROPIC ACTIVITY 1983
  • Ponomareva-Stepnaja M.A.
  • Nezavibat'Ko V.N.
  • Potaman V.N.
  • Val'Dman A.V.
  • Kozlovskaja M.M.
  • Val'Dman E.A.
  • Bondarenko N.A.
RU1124544C
AGENT EXHIBITING ANTIPSYCHOTIC ACTIVITY 2008
  • Andreeva Ljudmila Aleksandrovna
  • Mjasoedov Nikolaj Fedorovich
  • Zozulja Andrej Aleksandrovich
  • Kost Natalija Vsevolodovna
  • Meshavkin Viktor Konstantinovich
  • Voronina Tat'Jana Aleksandrovna
  • Garibova Taisija Leonovna
  • Seredenin Sergej Borisovich
RU2411248C2
MEDICATION, WHICH PRODUCES NOOTROPIC ACTION ON ORGANISM 2012
  • Kolobov Aleksandr Aleksandrovich
  • Nikiforovich Grigorij Valer'Janovich
  • Prusakov Aleksej Nikolaevich
  • Shpen' Vladimir Mikhajlovich
RU2517209C2
METHOD AND INTERMEDIATES FOR HEPTAPEPTIDE PRODUCTION 2006
  • Bespalova Zhanna Dmitrievna
  • Molokoedov Aleksandr Sergeevich
  • Ovchinnikov Mikhail Vladimirovich
  • Pal'Keeva Marina Evgen'Evna
  • Sidorova Marija Vladimirovna
RU2303603C2
FAMILY OF PEPTIDES POSSESSING ANALGESIC ACTIVITY 2005
  • Alfeeva Ljudmila Jur'Evna
  • Andreeva Ljudmila Aleksandrovna
  • Voronina Tat'Jana Aleksandrovna
  • Guzevatykh Ljudmila Sergeevna
  • Emel'Janova Tat'Jana Georgievna
  • Mjasoedov Nikolaj Fedorovich
  • Seredenin Sergej Borisovich
RU2286169C1
AC-HIS-ALA-GLU-GLU-NH PEPTIDE PRODUCTION METHOD 2021
  • Balaev Aleksandr Nikolaevich
  • Osipov Vasilij Nikolaevich
  • Okhmanovich Kirill Anatolevich
  • Chuev Vladimir Petrovich
  • Buzov Andrej Anatolevich
  • Simakov Sergej Vadimovich
RU2767030C1
METHOD FOR PREPARATION OF NONAPEPTIDIC OR DECAPEPTIDIC DERIVATIVES OF LH-RH HORMONE OR THEIRS PHARMACEUTICALLY ACCEPTABLE SALTS 0
  • Dzhon Dzhozef Nestor
  • Gordon Genri Dzhons
  • Brajan Genri Vikeri
SU1681733A3
HEPTAPEPTIDE ELICITING ANALGETIC ACTIVITY COMBINING WITH THERMOREGULATORY AND/OR VASOMOTOR ACTIVITY AND/OR WITH EFFECT ON BEHAVIOR RESPONSE OF TESTING ORGANISM AND METHOD OF ALTERNATION OF PHYSIOLOGICAL ACTIVITY OF DERMORPHINE 1997
  • Emel'Janova T.G.
  • Nezavibat'Ko V.N.
  • Usenko A.B.
  • Andreeva L.A.
RU2134121C1

RU 2 394 836 C2

Authors

Golubovich Vladimir Petrovich

Martinovich Vera Pavlovna

Evstigneeva Elena Borisovna

Kamenskij Andrej Aleksandrovich

Voskresenskaja Ol'Ga Georgievna

Kovalenko Aleksandr Pavlovich

Dates

2010-07-20Published

2008-09-12Filed