FIELD: chemistry.
SUBSTANCE: present invention relates to bioorganic chemistry and medicine and can be used to prepare medicinal agents with neurotropic activity. The technical result is achieved due to creation of a peptide with neurotropic activity and having general formula: Ac-X-Met-Pro-Arg-Gly-NH2, where X-Met - L-Met or DL-Met.
EFFECT: obtaining a novel compound - analogues of the C-terminal end of vasopressin which are capable of selectively bonding with different subtypes of vasopressin receptors and, as a result, have different types of neurotropic activity, have low toxicity and are suitable for simple intranasal administration.
5 ex
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HEPTAPEPTIDE ELICITING ANALGETIC ACTIVITY COMBINING WITH THERMOREGULATORY AND/OR VASOMOTOR ACTIVITY AND/OR WITH EFFECT ON BEHAVIOR RESPONSE OF TESTING ORGANISM AND METHOD OF ALTERNATION OF PHYSIOLOGICAL ACTIVITY OF DERMORPHINE | 1997 |
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Authors
Dates
2010-07-20—Published
2008-09-12—Filed