FIELD: medicine.
SUBSTANCE: genetically modified microorganisms having DNA encoding polypeptide involved in biosynthesis of macrolide compound of pladienolida, and DNA encoding polypeptide having hydroxylase activity aimed at pladyenolides hydroxylation in 16-position are proposed. The invention enables to produce effectively macrolide compound hydroxylated in the 16-position, directly in a single microorganism.
EFFECT: obtained compound has a high antitumor activity and can be used to develop anticancer drugs.
17 cl, 4 dwg, 7 tbl, 18 ex
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