FIELD: medicine.
SUBSTANCE: invention refers to pharmacology and medicine, particularly to endocrinology. A method for making proinsulin preparation consists that in 1-50 % aqueous polyethylene glycol with molar mass 0.4-40 kDa pre-exposed to ionising radiation in amount 1.0-5.0 Mrad in acid medium at pH 2.5 - 4.5 with calcium and/or zinc cations added to final concentration of 5-10 mm, proinsulin is introduced to final concentration of 1-10 mg/ml in the ratio of polyethylene glycol to proinsulin equal (1-500)/1. The mixture is stirred to prepare a homogeneous transparent or slightly opalescent solution.
EFFECT: use of the method allows simplifying process for making proinsulin preparation and ensuring possibility of its application as a hypoglycaemic agent and maintenance of activity at pH 2-3 and room temperature.
4 cl, 1 tbl, 4 ex
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