1, 5-NAPHTHYRIDINAZOLIDINONES EXHIBITING CDK1 ANTIPROLIFERATIVE ACTIVITY Russian patent published in 2010 - IPC C07D417/06 C07D417/14 A61K31/4375 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to a compound of formula I and to its pharmaceutically acceptable salts. In formula I , Y means -S- or -NH-; R₁ is specified from hydrogen, -C(O)O-[CH₂CH₂O]_P-R4, -C(O)-R₃ and R₂-(X)_n-; R₃ is specified from lower alkyl, cycloalkyl containing 3 to 6 carbon atoms and ; R₄ means lower alkyl; X is specified from lower alkylene and cyclisated lower alkylene; R₂ means ; where is specified from phenyl, and a 5 or 6-merous heteroaromatic ring containing 1 to 2 heteroatoms specified in the group consisting of sulphur and nitrogen; R₅ and R₆ are independently specified in the group including hydrogen, lower alkyl, halogen, perfluor (lower alkyl) and lower alkoxygroup; n means an integer within 1 to 2; and r means 0. The invention also concerns a pharmaceutical composition containing a therapeutically effective amount of the compound under the invention.

EFFECT: preparation of the new compounds which show CDK1 kinase inhibiting activity and can be effective in cancer treatment, particularly breast cancer, lung cancer, colon cancer and prostate cancer treatment.

64 cl, 27 ex