NOVEL BENZOTHIAZINONE DERIVATIVES AND USE THEREOF AS ANTIBACTERIAL AGENTS Russian patent published in 2010 - IPC C07D417/04 C07D491/10 A61K31/5415 A61P31/04 A61P31/06 

FIELD: chemistry.

SUBSTANCE: invention describes novel benzothiazinone derivatives of formula (I) and their use as antibacterial agents in infectious diseases caused by bacteria, especially mycobacterium tuberculosis (TB) and leprosy, in which R¹ and R² independently denote NO₂, CN, CONR⁷R⁸, COOR⁹ CHO, halogen, SO₂NR⁷R⁸, OCF₃, trifluromethyl; R³ and R⁴ independently denote H or methyl; R⁵ and R⁶ independently denote a straight or branched aliphatic radical having 1-8 members in the chain, or R⁵ and R⁶ together denote a divalent radical -(CR⁹ ₂)_m- or R⁵ and R⁶ together denote a divalent radical: R⁷, R⁸ and R⁹ independently denote H or a straight or branched aliphatic radical having 1-7 members in the chain, or phenyl.

EFFECT: design of an efficient method of obtaining benzothiazinone derivatives, a pharmaceutical composition having anti-mycobacterial activity.

12 cl, 6 tbl, 12 ex