METHOD OF SEPARATING 1-CARBAMOYLOXY-2-HYDROXY-3-(2-METHOXYPHENOXY)PROPANE INTO ENANTIOMERS Russian patent published in 2010 - IPC C07C215/08 C07B57/00 C07C269/08 

FIELD: chemistry.

SUBSTANCE: invention relates to chemistry of organic compounds, namely, to method of division into separate enantiomers of racemic 1-carbamoyloxy-2-hydroxy-3-(2-methoxyphenoxy)propane and lies in the following: at 50-55°C saturated water solution of racemic 1-carbamoyloxy-2-hydroxy-3-(2-methoxyphenoxy)propane, enriched with one of enentiomers, is prepared, mixed with gradual cooling to room temperature, achieving its supersaturation, after that crystalline seeding of the same enantiomer, which is added for enrichment, is introduced, kept while mixing and thermostating until maximal value of enantiomer excess of mother liquor is reached, scalemic 1-carbamoyloxy-2-hydroxy-3-(2-methoxyphenoxy)propane, possessing the same configuration as the sample of introduced seeding, is filtered; racemic compound is added into mother liquor, enriched with the second enantiomer, in amount that compensates separated sediment, heated to complete dissolution at 50-55°C, after that cooled to room temperature ensuring supersaturation, crystalline seeding of prevailing in solution enantiomer is introduced, kept while mixing and thermostating, sediment, enriched with the second enantiomer is separated with further repetition of said process for several times, with thorough analysis of enantiomer purity of target compound.

EFFECT: ensuring possibility to obtain enantiomers of methocarbamole (1-carbamoyloxy-2-hydroxy-3-(2-methoxyphenoxy)propane) of high optic purity from racemic mixture.

1 cl, 3 ex, 2 tbl