FIELD: chemistry.
SUBSTANCE: invention relates to a method for obtaining a compound by the formula I-a, executed wherein are (i) a reaction of ethyl nicotinate with N-vinylpyrrolidone in the presence of an alcoholate base resulting in 3-nicotinoyl-1-vinylpyrrolidin-2-one; (ii) a reaction of 3-nicotinoyl-1-vinylpyrrolidin-2-one with an acid resulting in myosmin; (iii) reduction of myosmin to nornicotine using a reducing agent; and (iv) methylation of nornicotine resulting in a compound by the formula Ia, wherein stage (ii) is executed using an inorganic acid, and wherein the method constitutes a one-pot process.
EFFECT: development of a method for producing a compound by the formula I-a constituting a one-pot process with a high yield and purity of the target compound.
15 cl, 4 tbl, 4 ex
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