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2 396 282

(13)

(51)

IPC

C08B37/10(2006-01-01)

C12P1/00(2006-01-01)

C12P19/04(2006-01-01)

A61P7/02(2006-01-01)

(21) (22)

Application

2009112010/13, 2009-04-02

(24)

Start date

2007-11-08

(22)

Actual filing date

2009-04-02

(45)

Published

2010-08-10

(72)

Inventor

Bannikova Galina Evgen'EvnaDrozd Natal'Ja NikolaevnaVarlamov Valerij PetrovichMakarov Vladimir AleksandrovichTolstenkov Aleksandr SergeevichLapikova Elena SergeevnaMiftakhova Nadzhija TairovnaIl'Ina Alla ViktorovnaLopatin Sergej AleksandrovichSkrjabin Konstantin Georgievich

(73)

Holder

Gosudarstvennoe Uchrezhdenie Gematologicheskij Nauchnyj Tsentr Rossijskoj Akademii Meditsinskikh Nauk Gnts Ramn)Tsentr Rossijskoj Akademii Nauk

METHOD FOR PREPARING HEPARIN WITH LOW MOLECULAR WEIGHT AND ANTICOAGULANT ACTIVITY Russian patent published in 2010 - IPC C08B37/10 C12P1/00 C12P19/04 A61P7/02

Abstract RU 2396282 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: there is offered a method for preparing low-molecular heparins by enzymatic degradation. For enzymatic depolymerisation, immobilised lysozyme is used.

EFFECT: prepared low-molecular heparin shows higher inhibitor activity with respect to blood coagulation factor Xa and lower inhibitor activity with respect to thrombin in comparison with initial heparin.

2 tbl, 3 ex

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RU 2 396 282 C1

Authors

Bannikova Galina Evgen'Evna

Drozd Natal'Ja Nikolaevna

Varlamov Valerij Petrovich

Makarov Vladimir Aleksandrovich

Tolstenkov Aleksandr Sergeevich

Lapikova Elena Sergeevna

Miftakhova Nadzhija Tairovna

Il'Ina Alla Viktorovna

Lopatin Sergej Aleksandrovich

Skrjabin Konstantin Georgievich

Dates

2010-08-10—Published

2009-04-02—Filed