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2 295 538

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IPC

C08B37/10(2006-01-01)

A61K31/727(2006-01-01)

(21) (22)

Application

2005105423/15, 2005-03-01

(24)

Start date

2005-03-01

(22)

Actual filing date

2005-03-01

(45)

Published

2007-03-20

(72)

Inventor

Drozd Natal'Ja NikolaevnaBannikova Galina Evgen'EvnaMakarov Vladimir AleksandrovichVarlamov Valerij PetrovichTikhonov Vladimir Evgen'EvichSkrjabin Konstantin Georgievich

(73)

Holder

Gematologicheskij Nauchnyj Tsentr RamnTsentr Ran

METHOD FOR PREPARING HEPARINS OF LOW MOLECULAR MASS Russian patent published in 2007 - IPC C08B37/10 A61K31/727

Abstract RU 2295538 C2

FIELD: medicine, biochemical technology.

SUBSTANCE: invention proposes a method for preparing low-molecular heparins using enzymatic cleavage. For enzymatic depolymerization the method involves using papain, chymotrypsin or complexes of hydrolases as components of preparations "Protease C" and celloviridine immobilized on silochrome or polyvinyl alcohol. Method provides preparing low-molecular heparins by effect of immobilized hydrolases with the yield of the end product about 70-80%.

EFFECT: improved preparing method.

8 ex

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RU 2 295 538 C2

Authors

Drozd Natal'Ja Nikolaevna

Bannikova Galina Evgen'Evna

Makarov Vladimir Aleksandrovich

Varlamov Valerij Petrovich

Tikhonov Vladimir Evgen'Evich

Skrjabin Konstantin Georgievich

Dates

2007-03-20—Published

2005-03-01—Filed