FIELD: chemistry.
SUBSTANCE: present invention relates to a method of producing a thiazole derivative of formula (3), involving a step for reacting a formula (1) compound with ammonia and formaldehyde to obtain a hexahydrotriazine derivative of formula (2), and then reacting with hydroxyl amine in acidic conditions 
, where X1 is a hydrogen atom or a halogen atom, X2 is a halogen.
EFFECT: invention relates to design of an efficient method of producing a thiazole derivative of formula (3), involving reaction of a hexahydrotriazine derivative of formula (2) with hydroxyl amine in acidic conditions.
8 cl, 12 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING THIAZOLE THROUGH AMINOMETHYLATION | 2005 |
|
RU2372340C2 |
| DERIVATIVES OF PYRIDONE CARBOXYLIC ACID, METHODS OF THEIR SYNTHESIS, ANTITUMOR AGENT AND PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2151770C1 |
| BENZIMIDAZOLE DERIVATIVES AND APPLICATION THEREOF FOR GAMMA-AMINO-BUTYRIC ACID (GABA) RECEPTOR COMPLEX MODULATION | 2006 |
|
RU2405779C2 |
| METHOD OF SYNTHESIS OF NITROGUANIDINE DERIVATIVES | 1998 |
|
RU2194039C2 |
| DERIVATIVES OF 1,3,5-OXADIAZINE OR ITS TAUTOMER AS A FREE COMPOUND OR SALT AND AN INSECTICIDE AGENT CONTAINING SAID | 1993 |
|
RU2127265C1 |
| METHOD FOR PREPARING THIAZOLE DERIVATIVES POSSESSING PESTICIDE ACTIVITY | 2001 |
|
RU2283314C2 |
| 0 |
|
SU231401A1 | |
| TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AS INDIVIDUAL ENANTIOMERS, RACEMATES OR OTHER ENANTIOMER MIXTURES | 1994 |
|
RU2135472C1 |
| DERIVATIVES OF NAPHTHYRIDINE AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF | 2000 |
|
RU2240322C2 |
| DERIVATIVES (INDOLE-3-YL) HETEROCYCLIC COMPOUNDS AS AGONISTS OF CANNABINOID RECEPTORS CB1 | 2005 |
|
RU2376302C2 |
