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2 397 162

(13)

(51)

IPC

C07D285/01(2006-01-01)

C07D417/12(2006-01-01)

C07D417/14(2006-01-01)

A61K31/4427(2006-01-01)

A61K31/5377(2006-01-01)

A61K31/41(2006-01-01)

A61K31/541(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2007133809/04, 2006-02-08

(24)

Start date

2006-02-08

(22)

Actual filing date

2006-02-08

(45)

Published

2010-08-20

(72)

Inventor

Fenstra Rulof V.Kejzer Khiskias G.Pras-Raves Marija L.Van Vliet Bernard J.Van Skharrenburg Gjustaf J.M.

(73)

Holder

Solvej Farmas'Jutikals B.V.

[1,2,4]-DITHIAZOLI(DI)NE DERIVATIVES, GLUTATHIONE-S-TRANSFERASE AND NADPH: QUINONE-OXIDOREDUCTASE FOR PREVENTION AND TREATMENT OF UNFAVOURABLE STATES ASSOCIATED WITH CYTOTOXICITY IN WHOLE AND APOPTOSIS PARTICULARLY Russian patent published in 2010 - IPC C07D285/01 C07D417/12 C07D417/14 A61K31/4427 A61K31/5377 A61K31/41 A61K31/541 A61P25/00

Abstract RU 2397162 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of general formula (I): wherein dashed lines present single or double bonds, and the values of radicals R1, R2, R3, R4 are described in cl. 1 of the patent claim. Besides the invention refers to application and a based pharmaceutical composition for prevention and treatment of neurodegenerative diseases and other diseases wherein cell dystrophy and/or cell loss (apoptosis) caused by free radicals act the main part.

EFFECT: production of new compounds and the based pharmaceutical composition which can find application in medicine for prevention and treatment of neurodegenerative diseases.

6 cl, 3 ex

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RU 2 397 162 C2

Authors

Fenstra Rulof V.

Kejzer Khiskias G.

Pras-Raves Marija L.

Van Vliet Bernard J.

Van Skharrenburg Gjustaf J.M.

Dates

2010-08-20—Published

2006-02-08—Filed