METHOD OF PREMEDICATION IN PRE-OPERATION CHEMICAL THERAPY IN PATIENTS WITH NON-SMALL CELL III STAGE LUNG CARCINOMA Russian patent published in 2010 - IPC A61K31/138 A61K31/573 A61P35/00 A61B5/155 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely, to oncology, and can be used in treatment of patients with non-small cell III stage lung carcinoma (NSCLC). For this purpose, first laboratory estimation of initial cortisol production is performed and in case of its normal indices carried out is pre-medication that includes intramuscular introduction of dexamethasone in accordance with the scheme: 20 mg 13 hours, 10 mg 7 hours and 10 mg 2 hours before carrying out chemical therapy with taxanes. Cortisol level is determined repeatedly immediately before infusion of taxanes and after operation. In case if level of peak cortisol secretion in post-operation period in early morning hours drops lower than 300 nmole/l drug correction with glucocorticosteroids is carried out additionally until normalisation of indices.

EFFECT: method allows to reduce number of post-operation complications in said category of patients due to preventive drug correction of possible adrenal insufficiency with simultaneous prevention of hypersensitivity responses to introduction of taxanes.

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