METHOD OF DIAGNOSING SEVERITY OF CELIAC DISEASE COURSE Russian patent published in 2010 - IPC G01N33/48 G01N33/53 

FIELD: medicine.

SUBSTANCE: essence of method of diagnosing celiac disease severity includes carrying out morphological examination, as well as detecting antibodies to gliadin, endomysium and tissue transglutaminase. In case of first degree of malabsorption antibodies are detected in concentration 10-29 IU/ml, basal membrane of epithelium and blood vessels, as well as of endomysium of smotth muscle cells is edematous and loosened. In case of second degree, concentration of antibodies constitutes 30-60 IU/ml and local destruction of basal membrane and nidal thinning of endomysium are observed. In case of third degree, level of antibodies constitutes 61 IU/ml and higher and extended destruction of basal membrane of epithelium and endothelium of blood vessels and nidal destruction of smooth muscle cells are observed.

EFFECT: increased accuracy of diagnosing severity of celiac disease course.

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