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(19)

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2 392 278

(13)

(51)

IPC

C07D413/04(2006-01-01)

C07D413/14(2006-01-01)

C07D401/04(2006-01-01)

C07D417/14(2006-01-01)

A61K31/538(2006-01-01)

A61K31/553(2006-01-01)

A61K31/498(2006-01-01)

A61P9/00(2006-01-01)

A61P25/04(2006-01-01)

A61P29/00(2006-01-01)

A61P37/08(2006-01-01)

(21) (22)

Application

2007105595/04, 2005-07-14

(24)

Start date

2005-07-14

(22)

Actual filing date

2005-07-14

(45)

Published

2010-06-20

(72)

Inventor

Koga JosikhisaJata SindziVatanabe TakasiMatsuo TakujaJamasaki TakajukiSakata MasakhiroKondo VataruOzeki KhidekazuKhori Josikazu

(73)

Holder

Dzhapan Tobakko Ink.

CONDENSED BENZAMIDE DERIVATIVE AND INHIBITOR OF VANILLOID RECEPTOR TYPE 1 ACTIVITY (VRI) Russian patent published in 2010 - IPC C07D413/04 C07D413/14 C07D401/04 C07D417/14 A61K31/538 A61K31/553 A61K31/498 A61P9/00 A61P25/04 A61P29/00 A61P37/08

Abstract RU 2392278 C2

FIELD: chemistry.

SUBSTANCE: benzamide derivatives are presented by the formula [1] or its salt, where Z is -O-, -NR⁵-, -S-, -SO-; 1 is 0 or 1; m is 0 or 1; R¹ is hydrogen atom, C1-6-alkyl group, R² is hydrogen atom, hydroxylic group, C1-6- alkyl group, carboxyl group, C1-6-alkoxycarbonyl group or -CONR¹⁰R¹¹, or R² and R¹ together form =O; R³ is hydrogen atom or C1-6-alkyl group; R⁴ is hydrogen atom or halogen atom; V is direct bond or -(CR²¹R²²)_n-; P1 and P2 rings are the same or different, and each is aromatic or saturated carbocyclic group, or 5-10-member saturated or unsaturated heterocyclic group containing 1-3 heteroatoms selected out of N, O, S.

EFFECT: obtainment of compound with excellent inhibition effect on vanilloid receptor type 1 activity, efficiency in treatment of diseases involving vanilloid receptor type 1 activity.

17 cl, 56 tbl, 8 ex

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RU 2 392 278 C2

Authors

Koga Josikhisa

Jata Sindzi

Vatanabe Takasi

Matsuo Takuja

Jamasaki Takajuki

Sakata Masakhiro

Kondo Vataru

Ozeki Khidekazu

Khori Josikazu

Dates

2010-06-20—Published

2005-07-14—Filed