IMPROVED METHOD FOR SYNTHESIS OF OXIDISED PHOSPHOLIPIDS Russian patent published in 2010 - IPC C07F9/10 

FIELD: chemistry.

SUBSTANCE: in the proposed methods, the hydroxyl group of the formula I compound is substituted with the corresponding residue so that use of column chromatography is avoided, , where A₁ is CH₂, R₁ is alkyl, R₃ is a residue of phosphoric acid, phosphorylcholine, phosphoryl ethanolamine, phosphorylserine, phosphoryl cardiolipin, phosphoryl inosite, ethylphosphocholine, phosphoryl methanol, phosphoryl ethanol, phosphoryl propanol, phosphoryl butanol, phosphoryl ethanolamine-N-lactose, phosphoethanolamine-N-[methoxy(propyleneglycol)], phosphoinosite-4-phosphate, phosphoinosite-4,5-biphosphonate, pyrophosphate, phosphoethanolaminediethylene-triaminepentaacetate, dinitrophenyl phosphoethanolamine, phosphogycerine or a reactive phosphorus-containing group which can convert to the said residues, or hydrogen.

EFFECT: design of methods of producing phospholipids, which avoid use of chromatography.

22 cl, 5 ex