WATER-SOLUBLE HYDROLYTICALLY STABLE ACTIVATED POLYMER, METHOD OF SYNTHESIS OF ACTIVATED POLYETHYLENE GLYCOL (VARIANTS), BIOLOGICALLY ACTIVE CONJUGATE Russian patent published in 2001 - IPC

FIELD: chemistry of organic polymers. SUBSTANCE: invention relates to active derivatives of polyethylene glycol and related hydrophilic polymers and to methods of their synthesis for using in modification of indices of surfaces and molecules. Water-soluble hydrolytically stable activated polymer has at least one active sulfone residue connected to polymer taken among polyalkylene oxides, poly- -hydroxyethylated polyols and polyolefinic alcohols being sulfone residue means: a) active ethylsulfone residue; b) SO₂-CH₂-CH₂-X where X is halogen; c) vinyl sulfone group having come from active ethylsulfone residue; d) CO-NH-CH₂-CH₂-SO₂-CH= CH₂; e) NH-CO-CH₂-CH₂-SO₂-CH= CH₂. Invention provides to obtain activated polymers with specific reactive capacity, stability in water that under reductive conditions form the more stable compounds with surfaces and molecules involving biologically active molecules. EFFECT: improved method of synthesis, valuable properties of polymers. 22 cl, 4 ex