FIELD: chemistry.
SUBSTANCE: invention relates to an improved method for synthesis of N-nicotinoyl-γ-amino butyric acid which is an intermediate product for production of highly effective nootropic preparation - sodium salt of N-nictinoyl-γ-amino butyric acid (picamilon). The desired product is obtained by reacting 2-pyrrolidone with sodium hydroxide at 115-130°C in an aqueous medium with subsequent removal of water, addition of ethyl ether of nicotinic acid at 115-145°C, removal of the ethyl alcohol formed, addition of water at 70-80°C, treatment with sulphuric acid at 40-60°C until pH 4.7-4.8 and extraction of the product.
EFFECT: method enables reduction of amount of hazardous substances used in the synthesis while maintaining high output of the product which has good effect on the environment.
1 tbl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF OBTAINING N-(ISO)NICOTINOYL- γ -AMINOBUTYRIC ACID AND ITS SODIUM OR POTASSIUM SALT | 2007 |
|
RU2337097C1 |
| 0 |
|
SU388554A1 | |
| AMIDOALKANOLNITRATES AND METHOD OF PREPARATION THEREOF | 1998 |
|
RU2147301C1 |
| METHOD FOR PREPARING N-NICOTINOYL-γ-AMINOBUTYRIC ACID | 2005 |
|
RU2294930C1 |
| METHOD OF PREPARING γ-AMINOBUTYRIC ACID | 1998 |
|
RU2154628C2 |
| 0 |
|
SU325232A1 | |
| SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITION ACTIVITY | 2000 |
|
RU2260008C2 |
| 4-P-IZOPROPOXIPHENYL-2-PIRROLIDONE POSSESSING ANTICONVULSIVE ACTIVITY | 1985 |
|
SU1269456A1 |
| 4[(4'-NICOTINOYLAMINO)BUTYROYLAMINO]BUTANOIC ACID, EXHIBITING NOOTROPIC ACTIVITY, AND METHOD OF PRODUCING SAID COMPOUND | 2010 |
|
RU2436772C2 |
| METHOD OF SYNTHESIS OF 4-AMINOBUTYRIC ACID | 2001 |
|
RU2202538C2 |
