FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to a method for synthesis of N-nicotinoyl-γ-aminobutyric acid. Method involves synthesis of mixed anhydride of nicotinic and pivalic acid by interaction of pivaloyl chloride with nicotinic acid in a solvent medium chosen from solvents of the 3-d toxicity class, for example, from acetone or butyl acetate in the presence of pyridine bases as catalyst followed by the acylation of reaction of γ-aminobutyric acid with prepared solution of mixed anhydride and the following isolation of the end substance from reaction mass. Invention provides increasing the yield of the end substance to 87.5% and substitution of high-toxic solvents for less toxic solvents.
EFFECT: improved method of synthesis.
3 cl, 2 ex
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