FIELD: chemistry, pharmacology.
SUBSTANCE: invention relates to method of obtaining N-(iso) nicotinoyl-γ- aminobutyric acid or its sodium (potassium) salt, which is realized by acidifying γ-aminobutyric acid with mixed anhydride of (iso)nicotinic and aliphatic carboxylic acid or alcoxy-carbonic acid, obtained by interaction of suspension of ammonium salt or alkaline metal salt of (iso)nicotinic acid with chloranhydride of aliphatic carboxylic acid or with chloranhydride of alcoxy-carbonic acid in aprotonic polar solvent medium or in mixture of polar aprotonic and inert solvent, which does not mix with water and forms with it azeotrope. Suspension of sodium (potassium) salt of (iso)nicotinic acid is obtained by interaction of (iso)nicotinic acid with sodium or potassium hydroxide in medium of mixture of polar aprotonic solvent and enert solvent, which does not mix with water and forms azeotrope with it, with further removal of water in form of azeotrope with inert solvent. Sodium (potassium) salt of N-(iso)nicotinoyl-γ-aminobutyric acid is obtained by interaction of N-(iso)nicotinoyl-γ-aminobutyric acid with sodium or potassium hydroxide with its simultaneous or consecutive sedimentation with water-soluble ketone or alcohol, further filtration and drying or by interaction of N-(iso)nicotinoyl-γ-aminobutyric acid with sodium or potassium hydroxide in mixture of polar aprotonic solvent and inert solvent, which does not mix with water and which forms azeotrope with it or, in medium of at least one inert solvent, which does not mix with water and forms azeotrope with it, with further removal of water from reaction mixture in form of azeotrope with inert solvent and product isolation by known methods. Method allows to obtain N-(iso)nicotinoyl-γ-aminobutyric acid and its sodium or potassium salt with 87-94% output in terms of (iso)nicotinic acid.
EFFECT: increase of product output, eliminating organic amins application and simplification of technology of target product obtaining.
9 cl, 9 ex
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